|
KMID : 0861020110260040115
|
|
Korea Journal of Herbology
2011 Volume.26 No. 4 p.115 ~ p.124
|
|
|
Therapeutic Effect of the Impatiens balsamina Linne Extract on the Membranous Nephropathy
|
|
Wi Gyeong
Yoo Ji-Hyun
Doh Eun-Soo
Chang Jun-Pok
Kill Ki-Jung
|
|
|
Abstract
|
|
|
Objective: Membranous nephropathy(MN) is one of the most common causes of nephrotic syndrome in adults.
MN has been defined as granular subepithelial deposition of IgG immune complexes along the glomerular
basement membrane(GBM). However, there is not a satisfactory treatment for MN. We aimed to identify the
effect of Impatiens balsamina Linne(IBL) treatment on cationic bovine serum albumin(cBSA)- induced MN in a
mouse model.
Methods: Mice were divided into 4 groups. The normal group was injected with saline. The Control group was
treated with cBSA(50 mg/kg i.p) only. The third group IBL-100, was treated with cBSA(50 mg/kg, i.p) and
IBL(100 mg/kg, p.o). The fourth group IBL-400, was treated with cBSA(50 mg/kg, i.p) and IBL (400 mg/kg,
p.o). After cBSA and IBL treatment for 6 weeks, we measured change of body weight, proteinuria, serum
albumin, total cholesterol, triglyceride, BUN, creatinine, IgA, IgM, IgG, TNF-α, IL-6 and IL-1β levels. The
morphologic changes of renal glomeruli were also observed with a light microscope.
Results: The level of proteinuria significantly decreased and serum albumin increased in groups treated with
cBSA and IBL extract compared with the control. The levels of serum triglyceride, BUN, IgG, TNF-α, IL-1β
significantly decreased in both IBL groups. In histological findings of kidney tissue, thickening of GBM
decreased in both IBL groups.
Conclusions: This study shows that IBL might be effective for treatment of acute stage MN. More clinical data
and studies are to be done for efficient application.
|
|
|
KEYWORD
|
|
|
Impatiens balsamina Linne(IBL), membranous nephropathy(MN), cationic bovine serum albumin(cBSA)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|